Background: Triple tracer meal experiments used to investigate organ glucose-insulin dynamics, such as\nendogenous glucose production (EGP) of the liver are labor intensive and expensive. A procedure was developed to\nobtain individual liver related parameters to describe EGP dynamics without the need for tracers.\nResults: The development used an existing formula describing the EGP dynamics comprising 4 parameters defined\nfrom glucose, insulin and C-peptide dynamics arising from triple meal studies. The method employs a set of partial\ndifferential equations in order to estimate the parameters for EGP dynamics. Tracer-derived and simulated data sets\nwere used to develop and test the procedure. The predicted EGP dynamics showed an overall mean R2 of 0.91.\nConclusions: In summary, a method was developed for predicting the hepatic EGP dynamics for healthy,\npre-diabetic, and type 2 diabetic individuals without applying tracer experiments.
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